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1

Synthesis of selected 3-substituted-pyrimido[5,4-e]1,2,4-triazine-5,7-diamines as potential folate antagonists

Leslie M. Werbel, Edward F. Elslager, Judith L. Johnson

Journal:

Journal of Heterocyclic Chemistry

Année:

1985

Fichier:

PDF, 276 KB

1985

2

Antimalarial drugs. 64. Synthesis and antimalarial properties of 1-imino derivatives of 7-chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and related structures

Kesten, Stephen J., Degnan, Margaret J., Hung, Jocelyn, McNamara, Dennis J., Ortwine, Daniel F., Uhlendorf, Susan E., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.86 MB

english, 1992

3

Synthesis and antimalarial properties of 2,4-diamino-6-[(aryl)thio, sulfinyl, and sulfonyl]pyrido[3,2-d]pyrimidines

Norman L. Colbry, Edward F. Elslager, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1984

Fichier:

PDF, 361 KB

1984

4

Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines

McNamara, Dennis J., Berman, Ellen M., Fry, David W., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 930 KB

english, 1990

5

Synthesis and physical properties of the antimalarial agent 4-(2-bromo-4, 5-dimethoxyphenyl)-1,1,7, 7-tetraethyldiethylenetriamine (RC-12) (WR-27,653)

Leslie M. Werbel, Edward F. Elslager, Marland P. Hutt, J. M. Vandenbelt

Journal:

Journal of Pharmaceutical Sciences

Année:

1967

Langue:

english

Fichier:

PDF, 317 KB

english, 1967

6

Etoposide (VP-16): Current status and new developments. Edited by B. F. Issell, F. M. Muggia, and S. K. Carter. Academic Press, Orlando, FL. 32887. 1984. 355 + xix pp. ISBN 0-12-375350-3. $30.00

Leslie M. Werbel

Journal:

Journal of Pharmaceutical Sciences

Année:

1985

Langue:

english

Fichier:

PDF, 159 KB

english, 1985

7

Pyrazole derivatives. 5. Synthesis and antineoplastic activity of 3-(2-chloroethyl)-3,4-dihydro-4-oxopyrazolo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide and related compounds

Cheng, C. C., Elslager, Edward F., Werbel, Leslie M., Leopold, Wilbur R.

Journal:

Journal of Medicinal Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 582 KB

english, 1986

8

Amodiaquine N-oxides and other 7-chloro-4-aminoquinoline n-oxides

Edward F. Elslager, Eva H. Gold, Frank H. Tendick, Leslie M. Werbel, Donald F. Worth

Journal:

Journal of Heterocyclic Chemistry

Année:

1964

Langue:

english

Fichier:

PDF, 610 KB

english, 1964

9

Synthesis of fused imidazo-heterocyclic systems

Leslie M. Werbel, Maria L. Zamora

Journal:

Journal of Heterocyclic Chemistry

Année:

1965

Langue:

english

Fichier:

PDF, 376 KB

english, 1965

10

Synthesis of 5,6-dihydro-8-methoxy-4H-imidazo[4,5,1-ij]quinolines and some related ring systems

Leslie M. Werbel, Josephine Battaglia, Maria L. Zamora

Journal:

Journal of Heterocyclic Chemistry

Année:

1968

Fichier:

PDF, 536 KB

1968

11

Antimalarial agents. 6-[ [(dialkylamino)alkyl]amino]-5,8-dimethoxyquinaldines

Edward F. Flslager, Marland P. Hutt, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1969

Langue:

english

Fichier:

PDF, 396 KB

english, 1969

12

[(Dialkylamino)alkyl]aminopyrimido[1,2-a]benzimidazoles,2,3-dihydro-1H-cyclopenta[4,5]pyrimido[1,2-a]benzimidazoles, and s-triazolo[1,5-a]pyrimidines as potential antimalarial agents

Leslie M. Werbel, Ann Curry, Edward F. Elslager, Carolyn A. Hess, Marland P. Hutt, Carl Youngstrom

Journal:

Journal of Heterocyclic Chemistry

Année:

1969

Langue:

english

Fichier:

PDF, 815 KB

english, 1969

13

2-Phenyl-5-(trichloromethyl)-1,3,4-oxadiazoles, A new class of antimalarial substances

Marland P. Hutt, Edward F. Elslager, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1970

Langue:

english

Fichier:

PDF, 515 KB

english, 1970

14

Folate antagonists. 6. Synthesis and antimalarial effects of fused 2,4-diaminothieno[2,3-d]pyrimidines

Edward F. Elslager, Patricia Jacob, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1972

Langue:

english

Fichier:

PDF, 556 KB

english, 1972

15

Folate antagonists. 7. Antimalarial, antibacterial, and antimetabolite effects of 2,4-Diamino-6-(benzyl and pyridylmethyl)-5,6,7,8-tetrahydropyrido[4,3-d] pyrimidines

Edward F. Elslager, Jane Clarke, Patricia Jacob, Leslie M. Werbel, J. D. Willis

Journal:

Journal of Heterocyclic Chemistry

Année:

1972

Langue:

english

Fichier:

PDF, 546 KB

english, 1972

16

Folate antagonists. 5. Antimalarial and antibacterial effects of 2,4-diamino-6-(aryloxy and aralkoxy)quinazoline antimetabolites

Edward F. Elslager, Jane Clarke, Judith Johnson, Leslie M. Werbel, John Davoll

Journal:

Journal of Heterocyclic Chemistry

Année:

1972

Langue:

english

Fichier:

PDF, 816 KB

english, 1972

17

Folate antagonists. 8. Synthesis and antimalarial effects of 2,4-Diamino-6-[(aryl and pyridyl)methyl]-6,7-dihydro-7-methyl-5H-pyrrolo[3,4-d] pyrimidines

Edward F. Elslager, Ann Curry, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1972

Langue:

english

Fichier:

PDF, 353 KB

english, 1972

18

Synthesis and antimalarial effects of 5,6-dichloro-2-[(4-||4-(diethylamino)-i-methylbutyl] amino||-6-methyl-2-pyrirnidinyl)amino] benzimidazole and related benzimidazoles and lH-imidazo[4,5-b] pyridines

Leslie M. Werbel, Ann Curry, Edward F. Elslager, Carolyn Hess

Journal:

Journal of Heterocyclic Chemistry

Année:

1973

Fichier:

PDF, 980 KB

1973

19

Synthesis of 5,5′[[[3-(dimethylamino)propyl]imino]]bis[3-(trichloromethyl)-1,2,4-thiadiazole] and related thiadiazoles as antimalarial agents

Edward F. Faslager, Judith Johnson, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1973

Fichier:

PDF, 752 KB

1973

20

Synthesis and antimalarial effects of 2-(3,4-dichloroanilino)-7-[[[(dialkylamino)alkyl]amino]]-5-methyl-s-triazolo[1,5-a]pyrimidines

Leslie M. Werbel, Edward F. Elslager, Vera P. Chu

Journal:

Journal of Heterocyclic Chemistry

Année:

1973

Fichier:

PDF, 309 KB

1973

21

Synthesis and antimalarial effects of [1]benzothieno[3,2-f]quinazoline-1,3-diamine

Judith Johnson, Edward F. Elslager, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1977

Fichier:

PDF, 446 KB

1977

22

Synthesis and antimalarial effects of N,N-dialkyl-6-(substituted phenyl)-1,2,4,5-tetrazin-3-amines

Leslie M. Werbel, Dennis J. Mcnamara, Norman L. Colbry, Judith L. Johnson, Margaret J. Degnan, Barbara Whitney

Journal:

Journal of Heterocyclic Chemistry

Année:

1979

Fichier:

PDF, 920 KB

1979

23

Folate antagonists. 14. Synthesis of pyrazino[2,3-f]quinazoline-8,10-diamines and related heterocycles as potential antimalarial agents (1,2)

Judith Johnson, Edward F. Elslager, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1979

Fichier:

PDF, 207 KB

1979

24

Synthesis of 6-(arylthio)- and 6-[(arylmethyl)thio] -1,2,4,5-tetrazin-3-amines and n-phenyl- and n-(phenylmethyl)-1,2,4,5-tetrazine-3,6-diamines as potential antimalarial agents

Judith L. Johnson, Barbara Whitney, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1980

Fichier:

PDF, 379 KB

1980

25

Folate antagonists. 16. Antimalarial and antibacterial effects of 2,4-diamino-6-[(heterocyclic)thio, sulfinyl, and sulfonyl]quinazolines

Edward F. Elslager, Patricia Jacob, Judith Johnson, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1980

Fichier:

PDF, 391 KB

1980

26

Folate antagonists. 17. Synthesis and biological properties of a 2,4-diamino-6-thioquinazoline analog of aminopterin

Leslie M. Werbel, Linda Newton, Edward F. Elslager

Journal:

Journal of Heterocyclic Chemistry

Année:

1980

Fichier:

PDF, 319 KB

1980

27

Synthesis of 3,4-dihydrothioxanthene-1,9-dione analogs as potential antimalarial agents

Jocelyn Hung, Dennis J. Mcnamara, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1983

Fichier:

PDF, 441 KB

1983

28

Investigations into the synthesis of 6-ethyl-5-(4-pyridinyl)-2,4-pyrimidinediamine as a potential antimalarial agent

Jocelyn Hung, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1984

Fichier:

PDF, 270 KB

1984

29

Studies on 8-aminoquinoline 1-oxide antimalarial agents

Judith L. Johnson, Donald F. Worth, Normal L. Colbry, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1984

Fichier:

PDF, 334 KB

1984

30

Synthesis of N4-(5-methoxy-7-benzofuranyl)-1,4-pentanediamine, an oxygen isostere of primaquine

Judith L. Johnson, Leslie M. Werbel

Journal:

Journal of Heterocyclic Chemistry

Année:

1985

Fichier:

PDF, 121 KB

1985

31

Synthesis and antimalarial activity of a series of 2,4-diamino-6-[(N-alkylanilino)methyl]quinazolines

Leslie M. Werbel, Edward F. Elslager, Linda S. Newton

Journal:

Journal of Heterocyclic Chemistry

Année:

1987

Fichier:

PDF, 289 KB

1987

32

Antimalarial drugs. 61. Synthesis and antimalarial effects of 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-6-alkylphenols and their N.omega.-oxides

Kesten, Stephen J., Johnson, Judith, Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 753 KB

english, 1987

33

Antischistosomal effects of 5-(2,4,5-trichlorophenyl)hydantoin and related compounds

Werbel, Leslie M., Elslager, Edward F., Islip, Peter J., Closier, M. D.

Journal:

Journal of Medicinal Chemistry

Année:

1977

Langue:

english

Fichier:

PDF, 481 KB

english, 1977

34

Antimalarial drugs. 50. Folate antagonists. 19. Synthesis and antimalarial effects of 6-(arylthio)-2,4-pteridinediamines

Elslager, Edward F., Johnson, Judith L., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1981

Langue:

english

Fichier:

PDF, 332 KB

english, 1981

35

Antimalarial drugs. 60. Synthesis, antimalarial activity, and quantitative structure-activity relationships of tebuquine and a series of related 5-[(7-chloro-4-quinolinyl)amino]-3-[(alkylamino)methyl][1,1'-biphenyl]-2-ols and N.omega.-oxides

Werbel, Leslie M., Cook, P. Dan, Elslager, Edward F., Hung, Jocelyn H., Johnson, Judith L., Kesten, Stephen J., McNamara, Dennis J., Ortwine, Daniel F., Worth, Donald F.

Journal:

Journal of Medicinal Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 1.84 MB

english, 1986

36

Folate antagonists. 18. Synthesis and antimalarial effects of N6-(arylmethyl)-N6-methyl-2,4,6-pteridinetriamines and related N6,N6-disubstituted 2,4,6-pteridinetriamines

Elslager, Edward F., Johnson, Judith L., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1981

Langue:

english

Fichier:

PDF, 693 KB

english, 1981

37

A new class of analog of the bifunctional radiosensitizer .alpha.-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines

Suto, Mark J., Stier, Michael A., Werbel, Leslie M., Arundel-Suto, Carla M., Leopold, Wilbur R., Elliott, William E., Sebolt-Leopold, Judith S.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 716 KB

english, 1991

38

The renewed potential for folate antagonists in contemporary cancer chemotherapy

Berman, E. M., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 921 KB

english, 1991

39

Antimalarial drugs. 63. Synthesis and antimalarial and antitumor effects of 2-amino-4-(hydrazino and hydroxyamino)-6-[(aryl)thio]quinazolines

Werbel, Leslie M., Degnan, Margaret J.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 558 KB

english, 1987

40

Derivatives of 2-amino-5-nitrothiazole as potential schistosomicides

Werbel, Leslie M., Battaglia, Josephine R.

Journal:

Journal of Medicinal Chemistry

Année:

1971

Langue:

english

Fichier:

PDF, 929 KB

english, 1971

41

Antimalarial drugs. 40. Folate antagonists. 12. Antimalarial and antibacterial effects of 2,4-diamino-6-[(aralkyl and alicyclic)thio-, sulfinyl-, and sulfonyl]quinazolines

Elslager, Edward F., Davoll, John, Jacob, Patricia, Johnson, A. M., Johnson, Judith, Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1978

Langue:

english

Fichier:

PDF, 565 KB

english, 1978

42

Antimalarial activity of 2-(substituted amino)-4,6-bis(trichloromethyl)-1,3,5-triazines and N-(chlorophenyl)-N'-[4-(substituted amino)-6-(trichloromethyl)-1,3,5-triazin-2-yl]guanidines

Werbel, Leslie M., Elslager, Edward F., Hess, Carolyn, Hutt, Marland P.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 634 KB

english, 1987

43

Folate antagonists. 21. Synthesis and antimalarial properties of 2,4-diamino-6-(benzylamino)pyrido[3,2-d]pyrimidines

Colbry, Norman L., Elslager, Edward F., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 497 KB

english, 1985

44

Repository drugs. VIII. Ester and amide congeners of amodiaquine, hydroxychloroquine, oxychloroquine, primaquine, quinacrine, and related substances as potential long-acting antimalarial agents

Elslager, Edward F., Tendick, Frank H., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1969

Langue:

english

Fichier:

PDF, 937 KB

english, 1969

45

Quinone Imides. XLVI. The Addition of Heterocyclic Active Methylene Compounds to p Benzoquinone Diimides

Adams, Roger, Werbel, Leslie M., Nair, M. D.

Journal:

Journal of the American Chemical Society

Année:

1958

Langue:

english

Fichier:

PDF, 327 KB

english, 1958

46

2-Nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells

Suto, Mark, Werbel, Leslie M

Journal:

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

Année:

1989

Langue:

english

Fichier:

PDF, 75 KB

english, 1989

47

Synthetic schistosomicides. XVII. N-(Benzylidene and cinnamylidene)-N'-[2-(diethylamino)ethyl]-1,4-naphthalenediamines and related Schiff bases

Elslager, Edward F., Battaglia, Josephine., Phillips, Annette A., Werbel, Leslie M.

Journal:

Journal of Medicinal Chemistry

Année:

1970

Langue:

english

Fichier:

PDF, 646 KB

english, 1970

48

Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

Showalter, H. D. Hollis, Johnson, Judith L., Hoftiezer, Jeanne M., Turner, William R., Werbel, Leslie M., Leopold, Wilbur R., Shillis, Joan L., Jackson, Robert C., Elslager, Edward F.

Journal:

Journal of Medicinal Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1987

49

Novel antituberculosis and antileprotic agents. 1-[3-[[5,6,7,8-tetrahydro-4-(phenylazo- and 3-pyridylazo)-1-naphthyl]amino]propyl]piperidines and related compounds

Werbel, Leslie M., Elslager, Edward F., Fisher, Myron W., Gavrilis, Zoe B., Phillips, Annette A.

Journal:

Journal of Medicinal Chemistry

Année:

1968

Langue:

english

Fichier:

PDF, 947 KB

english, 1968

50

5-Phenyl-2,4-pentadienamides as Potential Antimalarial Agents

Werbel, Leslie M., Headen, Nancy., Elslager, Edward F.

Journal:

Journal of Medicinal Chemistry

Année:

1967

Langue:

english

Fichier:

PDF, 589 KB

english, 1967